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Thrombotic Risk DNA Test

Are you at increased risk of abnormal blood clots?
The DNA Thrombotic Risk Test can tell you just that.

 

  • Includes variant in F5F2 and MTHFR genes
  • 100% private and confidential online results
  • Painless sample collection
  • Are you at increased risk of life-threatening blood clots?

$195.00

If you already took the DNA Thrombotic Risk Test, login to your Genebase account to access this app.
If you have not taken the DNA Thrombotic Risk Test, take the DNA test to access this app.

Detailed Description

Thrombosis is the formation of a blood clot inside a blood vessel, preventing the flow of blood through the circulatory system. Deep vein thrombosis (DVT) is the most common form of venous thrombosis (blood clot). DVT refers to a clot in a deep vein and it often happens in the leg. Symptoms in the affected area include pain, swelling, redness and warmth.

If you suspect a DVT you should contact a doctor as soon as possible, because sometimes the clot may break loose and travel to other parts of the body.

If the clot travels to the lungs, it can block essential blood vessels. This life-threatening complication is known as a pulmonary embolism (PE). Symptoms include a sudden shortness of breath, chest pain, coughing up blood-streaked mucus and a rapid heartbeat.

If the clot travels to the brain, it is also extremely dangerous and can potentially cause a cerebral venous thrombosis. Symptoms include impaired speech, difficulty moving parts of the body, vision problems and severe headaches.

Every year, more people die from a blood-clotting problem than breast cancer and HIV combined. All that is needed is a simple mouth swab to uncover your risk with this DNA test.

The Genetics

Genetic changes in three genes are analyzed in this thrombotic risk test. Each change contributes to an increased risk of thrombosis

  • F5 – the Factor V Leiden mutation (1691G>A)
  • F2 – the prothrombin mutation (20210G>A)
  • MTHFR – two mutations (677C>T and 1298A>C)

We inherit two copies of each gene – one from each parent. Therefore we can inherit two normal copies of a gene (homozygous normal), two copies that carry a genetic mutation (homozygous mutant), or one normal copy and one mutated copy (heterozygous). This means that we can inherit several different combinations of the F5F2 and MTHFR genes. Each combination is associated with a different risk of thrombophilia.

Patient Genotype

Thrombotic Risk

Factor V Leiden mutation (heterozygous 1691G>A) in the F5 gene

3X to 8X increased risk of thrombosis

2X to 11X increased risk of miscarriage

Factor V Leiden mutation (homozygous 1691G>A) in the F5 gene

10X to 80X increased risk of thrombosis

2X to 11X increased risk of miscarriage

Prothrombin mutation (heterozygous 20210G>A) in the F2 gene

2X to 5X increased risk of thrombosis

2X to 3X increased risk of miscarriage

Prothrombin mutation (homozygous 20210G>A) in the F2 gene

>5X increased risk of thrombosis

2X to 3X increased risk of miscarriage

Mutation (homozygous 677C>T) in the MTHFR gene

Increased risk of thrombosis if folate levels are low

Two mutations (677C>T and 1298A>C) in the MTHFR gene

Increased risk of thrombosis if folate levels are low

  • Maintain a healthy body weight
  • Follow a healthy diet
  • Increase your blood flow with exercise
  • Avoid extended periods of immobility
  • Avoid smoking
  • Reduce homocysteine levels by getting plenty of folate and other B vitamins
  • Wear compression stocking on long flights
  • If your risk is very high, seek medical treatment (e.g. anticoagulants)

How It Works

Order your test kit

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Test your DNA

A simple, painless mouth swab is all that’s needed

Get Results

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